Dexamethasone plus retinoids decrease IL‐6/IL‐6 receptor and induce apoptosis in myeloma cells
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چکیده
منابع مشابه
Rapamycin sensitizes multiple myeloma cells to apoptosis induced by dexamethasone.
Circumvention of chemoresistance in the B-cell neoplasm multiple myeloma (MM) might be achieved by targeting certain intracellular signaling pathways crucial for survival of the malignant clone. The use of the macrolide rapamycin, selectively inhibiting the phosphoprotein mammalian target of rapamycin (mTOR) downstream of, for example, insulin-like growth factor-I receptor (IGF-IR), possibly re...
متن کاملRapamycin Sensitizes Multiple Myeloma Cells to Apoptosis Induced by Dexamethasone Running title: Rapamycin and dexamethasone in multiple myeloma
word count: 199 Total text word count: 5877 Scientific heading: Neoplasia Blood First Edition Paper, prepublished online December 24, 2003; DOI 10.1182/blood-2003-05-1543 Copyright (c) 2003 American Society of Hematology For personal use only. on May 29, 2017. by guest www.bloodjournal.org From
متن کاملAnti-estrogens induce apoptosis of multiple myeloma cells.
Previous studies have suggested that multiple myeloma (MM) cells express estrogen receptors (ER). In the present study, we characterized the effects of estrogen agonists and antagonists (anti-estrogens [AE]) on growth of MM cell lines and MM patient cells. In addition to antagonizing estrogen binding to ER, AE can trigger apoptosis. Hence, we also determined whether estrogens or AE altered MM c...
متن کاملThe Probiotic Bacteria Induce Apoptosis in Breast and Colon Cancer Cells: An Immunostimulatory Effect
Background: Uncontrolled cell proliferation and resistance to apoptosis are the main characteristics of cancer cells. Therefore, a substance with the capability to induce apoptosis in cancer cells could be known as an anti-cancer material. Probiotics are useful microorganisms that are crucial for the host’s health.Materials and Methods: In the present stu...
متن کاملThe natural compound forskolin synergizes with dexamethasone to induce cell death in myeloma cells via BIM
We have previously demonstrated that activation of the cyclic adenosine monophosphate (cAMP) pathway kills multiple myeloma (MM) cells both in vitro and in vivo. In the present study we have investigated the potential of enhancing the killing of MM cell lines and primary MM cells by combining the cAMP-elevating compound forskolin with the commonly used MM therapeutic drugs melphalan, cyclophosp...
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ژورنال
عنوان ژورنال: British Journal of Haematology
سال: 1998
ISSN: 0007-1048,1365-2141
DOI: 10.1046/j.1365-2141.1998.00850.x